Kaposi's Sarcoma

Signs & symptoms

If there are signs of Kaposi's sarcoma (KS), a doctor will examine the skin and lymph nodes carefully. Lymph nodes are small, bean-shaped structures that are found throughout the body. They produce and store infection-fighting cells. The doctor also may recommend other tests to see if the patient has other diseases.

KS causes red or purple patches, called lesions, on the skin as well as on mucous membranes. It may spread to other organs in the body, such as the lungs, liver or intestinal tract.

Types

Patients are grouped depending on which type of Kaposi's sarcoma they have. There are three types of Kaposi's sarcoma:

• Classic Classic Kaposi's sarcoma is often described as occurring mainly in older men of Jewish, Italian or Mediterranean heritage. However, it also is relatively more common throughout much of sub-Saharan Africa, South America, the Middle East and the former Soviet Union and Eastern Europe than in Western Europe and the United States.This type of Kaposi's sarcoma progresses slowly, sometimes over a period of 10 to 15 years. As the disease gets worse, the lower legs may swell and the blood may not be able to flow properly. After some time, the disease may spread to other organs.
• Immunosuppressive-Treatment Related Kaposi's sarcoma may occur in people who are taking drugs called immunosuppresants to make their immune systems weaker. The immune system helps the body fight off infection. People who have had organ transplants, such as a liver or kidney transplants, have to take drugs to prevent their immune systems from attacking the new organs.
• Epidemic Kaposi's sarcoma in patients who have AIDS is called epidemic Kaposi's sarcoma. It usually spreads more quickly than other kinds of Kaposi's sarcoma and often is found in many parts of the body.

Treatments

Four kinds of treatment generally are used to treat patients with Kaposi's sarcoma:

• Surgery to remove the cancer
• Chemotherapy, using drugs to kill cancer cells
• Radiation therapy, using high-dose X-rays to kill cancer cells
• Biological therapy, using the body's immune system to fight cancer

Surgery

Surgery means removing the cancer. A doctor may remove the cancer using one of the following:

• Surgically cutting out the lesion and some of the tissue around it
• Electrodesiccation and curettage to burn the lesion and remove it with a sharp instrument
• Cryotherapy to freeze the tumor and kill it

Chemotherapy

Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill or it may be put into the body by a needle in a vein or muscle.

Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body and can kill cancer cells outside the original site. Because Kaposi's sarcoma is a systemic disease, often developing in several different locations at once, a systemic treatment often is needed.

A safe and fairly effective chemotherapy drug commonly used to treat Kaposi's sarcoma is liposomal doxorubicin, known as Doxil. Chemotherapy for Kaposi's sarcoma also may be injected into the lesion, a treatment called intralesional chemotherapy.

Radiation Therapy

Radiation therapy uses high-dose X-rays or other high-energy rays to kill cancer cells and shrink tumors. Radiation therapy used to be a common treatment of Kaposi's sarcoma but it is a local treatment for a disease that often is widespread. Another limitation is that it can only be used at each location, yet KS tends to recur.

Biological Therapy

Biological therapy tries to get the body to fight the cancer. It uses materials made by the body or made in a laboratory to boost, direct or restore the body's natural defenses against disease. Biological therapy is sometimes called biological response modifier (BRM) therapy or immunotherapy. Interferon can be useful for some patients with KS, especially if their immune systems are relatively healthy.