Skip to Main Content

Lewy Body Dementia

Overview

Lewy body dementia can occur alone or with other neurodegenerative conditions such as Alzheimer's or Parkinson's disease. It is the second most frequent cause of dementia in elderly adults and is associated with abnormal structures called Lewy-bodies found in certain areas of the brain.

Lewy bodies are abnormal protein deposits — smooth, round lumps in the nerve cells of the brain — that disrupt the brain's normal functioning. They're found throughout the outer layer or cerebral cortex of the brain and deep inside the midbrain and brainstem.

Frederich Lewy, a neurologist and contemporary of Alois Alzheimer, first identified these abnormal protein deposits in 1912.

Researchers don't yet understand if dementia with Lewy bodies is a distinct disease or a variation of Alzheimer's or Parkinson's disease. Symptoms can mimic those of Parkinson's disease or Alzheimer’s disease.

Our Approach to Lewy Body Dementia

As a world leader in the field of dementia disorders, UCSF provides comprehensive assessments and care for people with Lewy body dementia. We work with patients to find the right medications to alleviate symptoms. We may also recommend speech therapy to improve communication and physical therapy to stretch and strengthen stiff muscles.

Awards & recognition

  • U S  News and World Report badge recognizing UCSF as part of its 2024-2025 Honor Roll

    Among the top hospitals in the nation

  • U S  News and World Report badge recognizing UCSF as number 3 in the country for neurology and neurosurgery for 2024 to 2025

    Best in the West and No. 3 in the nation for neurology & neurosurgery

Signs & symptoms

Symptoms of Lewy body dementia include:

  • Progressive cognitive decline, memory loss and confusion
  • Fluctuating ability to comprehend and focus attention
  • Recurring visual hallucinations that are typically detailed
  • Symptoms similar to Parkinson's disease such as stiff muscles and shuffling gait.

Unlike Alzheimer’s disease, which tends to progress gradually, this disease often starts rapidly, with a fast decline in the first few months. Later, there may be some leveling off but Lewy body dementia typically progresses faster than Alzheimer's. A patient can survive from five to seven years with the disease.

Diagnosis

Lewy body dementia is difficult to diagnose because its symptoms are similar to other conditions. An extensive neurological and neuropsychological evaluation will be conducted, including brain imaging in an effort to identify degeneration of the brain.

As with many dementias, a definitive diagnosis can only be made with an autopsy when Lewy bodies in brain tissue can be seen.

In addition to the most common symptoms, patients with Lewy body dementia may experience the following:

  • Difficult sleeping or physically active during sleep
  • Fainting and periodic loss of consciousness
  • High sensitivity to drugs used treat hallucinations
  • Repeated falls

Treatments

Because there is no cure for Lewy body dementia, doctors try to treat and manage symptoms of the disease. Medications used to treat Alzheimer's and Parkinson's disease have been effective in some patients but must be closely monitored because patients with Lewy body dementia tend to be highly sensitive to drugs that affect the brain and can experience adverse side effects.

Medicatiions are usually initially administered at a low dose and slowly increased over time.

Tranquilizers and anti-psychotic drugs such as haloperidol or thioridazine, are sometimes used to help lessen symptoms such as agitation or hallucinations.

Patients have been especially responsive to cholinesterase inhibitors, used to treat Alzheimer's, to improve memory and cognition and reduce hallucinations.

The drug Levodopa or other Parkinson's disease medications may be given to treat the Parkinson's disease-like symptoms, to improve muscle stiffness and improve walking.

UCSF Health medical specialists have reviewed this information. It is for educational purposes only and is not intended to replace the advice of your doctor or other health care provider. We encourage you to discuss any questions or concerns you may have with your provider.

Recommended reading

Healthy Aging

Most healthy older adults experience mild decline in some areas of cognition, such as visual and verbal memory, immediate memory or the ability to name objects.

Memory and Aging Glossary

Use this memory and aging glossary to help navigate some of the esoteric terminology including, Agnosia, Aphasia, Gray Matter, Tau, Vacuolation, and more.

Where to get care (1)

    Support services

    ""
    Patient Resource

    Case Management & Social Work

    Connect with a team that can help you find resources, solve problems and advocate for you during treatment at UCSF.

    Support Group

    Memory & Aging Disorders Support Groups

    Find support for caregivers, families and patients dealing with dementia, early-onset Alzheimer's, Huntington's disease and more.

    Class

    Mindfulness-Based Stress Reduction Class

    This eight-week class teaches mindfulness practices that can reduce stress and improve your overall health, such as meditation and body awareness.

    Patient Resource

    Patient Relations

    We welcome feedback about your experience at UCSF Health. Find out how to contact us with comments, questions or concerns.

    Patient Resource

    Spiritual Care Services

    Chaplains representing many faiths are available around the clock to provide support, comfort and counsel to patients, families and caregivers.

    Share